Dr. Bishan Mahadevia's - Latest Tips and Resources

Tuesday, March 29, 2011

Transplanting Crown

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Transplanting in crown with early hair loss has following drawback in your case at this stage and age of hair loss;
1. The miniaturized weak existing hairs in this area may not be able to sustain the surgery and some of them may be lost sometime after this procedure ( shock loss)
2. The Transplant may be possible between the existing hairs so we can only put small number of hairs without damaging the existing hairs
3. If you lose more hair in future around the area of transplant you will have central are of transplanted hair with surrounding halo of no hairs ; this will not look natural.
4. You can certainly improve the area by use of medications then why you need surgery?

 Photo from: http://www.bernsteinmedical.com/hairtransplantblog/can-the-hair-grafts-be-packed-together-densely/

Tuesday, March 15, 2011

Astressin-B Potential new treatment for hair loss & gray hair

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According to an article published in on line journal Plosone.org Million Mulugeta, D.V.M., Ph.D., co-director of UCLA’s preclinical stress biology research program at the University of California, Los Angeles, claim that they have uncovered a promising hair-loss treatment & may have the potential to affect hair color, including gray hair..
The experiment wasn’t focused on hair loss. Instead, it was designed to study a chemical compound that blocks the effects of stress on the gut.

The research team, during a study of the effect of a compound called Astressin-B while conducting stress-hormone experiments on mice that typically develop head-to-tail baldness as a result of being genetically altered to overproduce a stress hormone (The mice used in the experiments had been genetically altered to overproduce a stress hormone called corticotrophin-releasing factor, or CRF. Corticotropin-releasing factor over-expressing (CRF -OE)-mice that display phenotypes of Cushing's syndrome and chronic stress, including alopecia. CRF-OE mice develop bilateral symmetric hair loss in adulthood). The goal of the experiments was to study the effect of Astressin-B ((5 µg/mouse) injected peripherally once a day for 5 days) to determine whether it would block the effects of stress on the colon but accidental finding was the mice treated with Astressin –B had recovered the full cover of fur on the back in few weeks compared to the placebo ( injected with saline) given mice which did not recover. A sterssin-B induced pigmentation and hair re-growth that was largely retained for over 4 months (a significant period for average 2 years life of mouse) when mice were killed Histological examination indicated that alopecic CRF-OE mice had hair follicle atrophy and that Astressin-B revived the hair follicle from the telogen to anagen phase.

The team repeated the experiment several times and got the same results — bald mice grew new hair in a few weeks. The researchers also injected the compound into young mice before they went bald. Those mice never lost their fur.

The researcher said the compound appears to have affected the mice skin pigment as well as spurred hair growth. This could mean Astressin-B has the potential to affect hair color and gray hairs. Majority of Pigments were regained by about 1 week and the hair was regained by about 2 weeks

Temporary blockade of the CRF receptors could thus be a breakthrough therapy for alopecia particularly for patients in acute (chemotherapy, traumatic stressful events) or chronic stress setting.

Findings of a mouse study may not be applicable to humans, but results may spur more study of the role stress might play in human hair loss. Hair growth cycles are very different in mice and humans, so one could draw only limited conclusions from the research

The research would probably be useful only for hair loss related to stress, likes that caused by one-time events, rather than as a treatment for genetic baldness.


Sunday, March 6, 2011

Scalp cloning vs. Hair cloning?

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Your thought is ingenious but the scalp transplant would involve very major surgery under general anesthesia with higher risks. More over it will have circumferential scarring, which may not look natural.


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